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MediFocus MedCenter ©
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 Bladder Cancer
(OC001)
Introduction


Bladder cancer is the fifth most common cancer in men and the seventh in women with an annual incidence of approximately 18 cases per 100,000 in the United States. Bladder cancer is three times more common in men than in women and primarily affects older persons with 80% of cases in the 50-79 year age group.

When found and treated early, the chances of survival are very good with a five-year survival rate for early bladder cancer approximating 94%.

There are several different types of bladder cancer. Of all bladder cancers, 75% are superficial at the time of diagnosis. However, some types may spread through the lining of the bladder and invade its muscular wall. This is known as invasive bladder cancer. Invasive cancer may extend through the bladder wall and spread to nearby organs. Common sites of distant metastasis include the brain, bone, and lung.

The choice of treatment depends on the stage of the disease, the presence of other medical conditions, and the person's preferences. Treatment usually consists of a combination of surgery, radiation, chemotherapy and/or immunotherapy.

Get the Facts... With your MediFocus Guide


The Medifocus Guide on Bladder Cancer provides answers to the following important questions and medical issues:

What are the most common symptoms of bladder cancer?
Are there any recognized risk factors for developing bladder cancer?
What kinds of medical tests are used to establish the diagnosis of bladder cancer?
What is the current standard of care for the treatment of bladder cancer?
What treatment options are available for the management of bladder cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in bladder cancer?
Where are the leading hospitals and centers of research for bladder cancer?
What are the most important questions to ask my doctor about bladder cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Levelling-off of the risk of lung and bladder cancer in heavy smokers: an analysis based on multicentric case-control studies and a metabolic interpretation.
Mutation Research. 2000
Carcinosarcoma of the urinary bladder--an aggressive tumor with diverse histogenesis. A clinicopathologic study of 4 cases and review of the literature.
Archives of Pathology & Laboratory Medicine. 2000
Bladder cancer: a review of diagnosis and management.
Journal of the National Medical Association. 2000
N-acetyltransferase 2 and bladder cancer: an overview and consideration of the evidence for gene-environment interaction.
British Journal of Cancer. 2000
New developments in the use of monoclonal antibodies in the therapy of genitourinary cancer.
Bju International. 2000
Management of superficial bladder cancer with intravesical chemotherapy: an update.
Urology. 2000
Gene therapy for bladder cancer.
World Journal of Urology. 2000
Rethinking the secondary prevention of superficial bladder cancer: is there a role for retinoids?.
Bju International. 2000
Urinary markers of malignancy.
Clinica Chimica Acta. 2000
Gemcitabine in locally advanced and/or metastatic bladder cancer.
Critical Reviews in Oncology-Hematology. 2000
MediFocus Guides... When You Need Trustworthy Medical Information


MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.






MediFocus MedCenter ©

 Breast Cancer, Early Stage
(OC002)
Introduction


Breast cancer is the most common cancer among women, other than skin cancer. It is the second leading cause of cancer death in women after lung cancer. The American Cancer Society predicts that there will be about 182,000 new cases of invasive breast cancer in the year 2000. Fortunately, deaths from breast cancer have declined significantly, which is though to be due to better detection and improved treatment.

There are usually no symptoms in the early stages of the disease. Screening by breast exam and regular mammogram as recommended greatly increases the chance of early diagnosis and is important for women of all ages.

Once a breast cancer is diagnosed, the focus of care depends on the stage of disease and the personal goals of the individual. An elderly woman with a less aggressive type of cancer may wish to avoid aggressive treatments and pursue palliative treatments, while for a younger woman, aggressive therapy targeted at achieving remission is usually desired.

Treatment strategy depends on the stage of disease and the goals of care for the individual. Treatment usually consists of a combination of surgery, medication, radiation, and/or chemotherapy.

Get the Facts... With your MediFocus Guide


The Medifocus Guide on Breast Cancer, Early Stage provides answers to the following important questions and medical issues:

What are the most common symptoms of breast cancer?
Are there any recognized risk factors for developing breast cancer?
What kinds of medical tests are used to establish the diagnosis of breast cancer?
What is the current standard of care for the treatment of breast cancer?
What treatment options are available for the management of breast cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in breast cancer?
Where are the leading hospitals and centers of research for breast cancer?
What are the most important questions to ask my doctor about breast cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Ovarian ablation for premenopausal early-stage breast cancer: an update.
Tumori. 2000
Health food store recommendations for breast cancer patients.
Archives of Family Medicine. 2000
Ductal carcinoma in situ (DCIS) of the breast: evolving perspectives.
Cancer Treatment Reviews. 2000
Primary systemic therapy in operable breast cancer.
Journal of Clinical Oncology. 2000
Should internal mammary lymph nodes in breast cancer be a target for the radiation oncologist?.
2000
Treatment of early-stage breast cancer in elderly women.
Medical & Pediatric Oncology. 2000
Treatment of early-stage breast cancer.
Current Problems in Cancer. 1999
Adjuvant systemic management of early stage carcinoma of the breast.
Surgical Oncology. 1999
The evaluation of high risk and pre-invasive breast lesions and the decision process for follow up and surgical intervention.
Surgical Oncology. 1999
From Halsted to prevention and beyond: advances in the management of breast cancer during the twentieth century.
European Journal of Cancer. 1999
MediFocus Guides... When You Need Trustworthy Medical Information


MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.






MediFocus MedCenter ©

 Breast Cancer, Locally Advanced
(OC003)
Introduction


Breast cancer is the most common cancer among women, other than skin cancer. It is the second leading cause of cancer death in women after lung cancer. The American Cancer Society predicts that there will be about 182,000 new cases of invasive breast cancer in the year 2000. Fortunately, deaths from breast cancer have declined significantly, which is though to be due to better detection and improved treatment.

Screening by breast exam and regular mammogram as recommended greatly increases the chance of early diagnosis and is important for women of all ages.

Once a breast cancer is diagnosed, the focus of care depends on the stage of disease and the personal goals of the individual. An elderly woman with a less aggressive type of cancer may wish to avoid aggressive treatments and pursue palliative treatments, while for a younger woman, aggressive therapy targeted at achieving remission is usually desired.

Treatment strategy depends on the stage of disease and the goals of care for the individual. Treatment usually consists of a combination of surgery, medication, radiation, and/or chemotherapy.

Get the Facts... With your MediFocus Guide


The Medifocus Guide on Breast Cancer, Locally Advanced provides answers to the following important questions and medical issues:

What are the most common symptoms of breast cancer?
Are there any recognized risk factors for developing breast cancer?
What kinds of medical tests are used to establish the diagnosis of breast cancer?
What is the current standard of care for the treatment of breast cancer?
What treatment options are available for the management of breast cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in breast cancer?
Where are the leading hospitals and centers of research for breast cancer?
What are the most important questions to ask my doctor about breast cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Health food store recommendations for breast cancer patients.
Archives of Family Medicine. 2000
Preliminary report concomitant irradiation and paclitaxel as radiosensitizer to increase the operability of unresectable locally advanced breast cancer.
Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 2000
New advances in the treatment of locally advanced non-small cell lung cancer and breast cancer.
Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 2000
Locally advanced breast cancer and postmastectomy radiotherapy.
Surgical Oncology Clinics of North America. 2000
The impact of chemotherapy dose density and dose intensity on breast cancer outcome: what have we learned?.
European Journal of Cancer. 2000
Docetaxel: an update of its use in advanced breast cancer.
Drugs. 2000
Molecular detection of micrometastases and circulating tumor cells in melanoma prostatic and breast carcinomas.
In Vivo. 2000
Primary systemic therapy in operable breast cancer.
Journal of Clinical Oncology. 2000
Socioeconomic factors and breast carcinoma in multicultural women.
Cancer. 2000
Current and potential chemotherapeutic agents used for induction chemotherapy in the treatment of breast cancer.
Current Pharmaceutical Design. 2000
MediFocus Guides... When You Need Trustworthy Medical Information


MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.







MediFocus MedCenter ©

 Breast Cancer, Metastatic
(OC004)
Introduction


Breast cancer is the most common cancer among women, other than skin cancer. It is the second leading cause of cancer death in women after lung cancer. The American Cancer Society predicts that there will be about 182,000 new cases of invasive breast cancer in the year 2000. Fortunately, deaths from breast cancer have declined significantly, which is though to be due to better detection and improved treatment.

Screening by breast exam and regular mammogram as recommended greatly increases the chance of early diagnosis and is important for women of all ages.

Once a breast cancer is diagnosed, the focus of care depends on the stage of disease and the personal goals of the individual. An elderly woman with a less aggressive type of cancer may wish to avoid aggressive treatments and pursue palliative treatments, while for a younger woman, aggressive therapy targeted at achieving remission is usually desired.

Treatment strategy depends on the stage of disease and the goals of care for the individual. Treatment usually consists of a combination of surgery, medication, radiation, and/or chemotherapy.

Get the Facts... With your MediFocus Guide


The Medifocus Guide on Breast Cancer, Metastatic provides answers to the following important questions and medical issues:

What are the most common symptoms of breast cancer?
Are there any recognized risk factors for developing breast cancer?
What kinds of medical tests are used to establish the diagnosis of breast cancer?
What is the current standard of care for the treatment of breast cancer?
What treatment options are available for the management of breast cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in breast cancer?
Where are the leading hospitals and centers of research for breast cancer?
What are the most important questions to ask my doctor about breast cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Health food store recommendations for breast cancer patients.
Archives of Family Medicine. 2000
Trastuzumab in the treatment of metastatic breast cancer : anticancer therapy versus cardiotoxicity.
Circulation. 2000
Bisphosphonates and the prevention of metastasis: first evidences from preclinical and clinical studies.
Cancer. 2000
Molecular mechanisms of osteolytic bone metastases.
Cancer. 2000
21-day oral etoposide for metastatic breast cancer: a phase II study and review of the literature.
American Journal of Clinical Oncology. 2000
Multidisciplinary care for patients with breast cancer.
Surgical Clinics of North America. 2000
High-dose chemotherapy and autologous stem cell transplantation for breast cancer.
Cancer Investigation. 2000
Endocrine therapy for breast cancer.
Oncology (Huntington). 2000
Systematic reviews of chemotherapy and endocrine therapy in metastatic breast cancer.
Cancer Treatment Reviews. 2000
Sentinel lymph node biopsy for the detection of metastases.
Cancer Journal From Scientific American. 2000
MediFocus Guides... When You Need Trustworthy Medical Information


MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.







MediFocus MedCenter ©

 Breast Cancer, Recurrent
(OC005)
Introduction


Breast cancer is the most common cancer among women, other than skin cancer. It is the second leading cause of cancer death in women after lung cancer. The American Cancer Society predicts that there will be about 182,000 new cases of invasive breast cancer in the year 2000. Fortunately, deaths from breast cancer have declined significantly, which is thought to be due to better detection and improved treatment.

Screening by breast exam and regular mammogram as recommended greatly increases the chance of early diagnosis and is important for women of all ages. Recurrent cancer means the disease has recurred despite initial treatment. Most recurrences appear within the first 2 or 3 years but can occur many years later.

Once a breast cancer is diagnosed, the focus of care depends on the stage of disease and the personal goals of the individual. An elderly woman with a less aggressive type of cancer may wish to avoid aggressive treatments and pursue palliative treatments, while for a younger woman, aggressive therapy targeted at achieving remission is usually desired.

Treatment strategy depends on the stage of disease and the goals of care for the individual. Treatment usually consists of a combination of surgery, medication, radiation, and/or chemotherapy.

Get the Facts... With your MediFocus Guide


The Medifocus Guide on Breast Cancer, Recurrent provides answers to the following important questions and medical issues:

What are the most common symptoms of breast cancer?
Are there any recognized risk factors for developing breast cancer?
What kinds of medical tests are used to establish the diagnosis of breast cancer?
What is the current standard of care for the treatment of breast cancer?
What treatment options are available for the management of breast cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in breast cancer?
Where are the leading hospitals and centers of research for breast cancer?
What are the most important questions to ask my doctor about breast cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Hormone-modulating herbs: implications for women's health.
Journal of the American Medical Womens Association. 1999
Pregnancy after breast cancer: from psychosocial issues through conception.
Oncology. 1998
Systemic adjuvant therapy of breast cancer.
Journal of Surgical Oncology. 1997
Intraductal carcinoma of the breast: pathologic features associated with local recurrence in patients treated with breast-conserving therapy.
American Journal of Surgical Pathology. 2000
Role of isolated locoregional recurrence of breast cancer: results of four prospective studies.
Journal of Clinical Oncology. 2000
Outcomes and factors impacting local recurrence of ductal carcinoma in situ.
Cancer. 2000
Local recurrence following breast conservation therapy in African-American women with invasive breast cancer.
American Journal of Surgery. 2000
Immunohistochemical study on primary and recurrent tumors in patients with local recurrence in the conserved breast.
Oncology Reports. 2000
Survival and pattern of failure following locoregional recurrence of breast cancer.
Clinical Oncology (Royal College of Radiologists). 1999
Quality of life in women with recurrent breast cancer.
1999
MediFocus Guides... When You Need Trustworthy Medical Information


MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.




MediFocus MedCenter ©

 Cervical Cancer
(OC006)
Introduction


Cervical cancer is the second most common type of cancer in women worldwide, after breast cancer. The American Cancer Society predicts that there will be about 12,800 new cases of invasive cervical cancer in the year 2000. There are several different types of cancer of the cervix.

Cancers of the cervix can take many years to develop and there are usually no symptoms for a long period before the disease becomes evident. Therefore, routine screening is critical to detect early changes and prevent progression to invasive disease.

About 85-90% are squamous cell carcinomas. The other 10-15% are adenocarcinomas. If the cancer has both types it is called mixed (adenosquamous) carcinoma.

When diagnosed early, most cervical cancers are curable. The key to good outcome is early detection and prompt treatment. Regular routine screening is critical to detecting early changes and preventing progression to advanced disease.

Treatment consists usually of a combination of surgery and chemotherapy, radiation, and/or biologic therapy.

Get the Facts... With your MediFocus Guide


The Medifocus Guide on Cancer of the Cervix provides answers to the following important questions and medical issues:

What are the most common symptoms of cancer of the cervix?
Are there any recognized risk factors for developing cancer of the cervix?
What kinds of medical tests are used to establish the diagnosis of cancer of the cervix?
What is the current standard of care for the treatment of cancer of the cervix?
What treatment options are available for the management of cancer of the cervix?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in cancer of the cervix?
Where are the leading hospitals and centers of research for cancer of the cervix?
What are the most important questions to ask my doctor about cancer of the cervix?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Human papillomavirus-positive well-differentiated villoglandular adenocarcinoma of the uterine cervix: A case report and review of the literature.
Gynecologic Oncology. 2000
Surgery for cervical intraepithelial neoplasia.
Cochrane Database of Systematic Reviews [computer file]. 2000
Interventions for encouraging sexual lifestyles and behaviours intended to prevent cervical cancer.
Cochrane Database of Systematic Reviews [computer file]. 2000
Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review.
Annals of Internal Medicine. 2000
Prevention of cervix cancer.
Critical Reviews in Oncology-Hematology. 2000
Risk factors for pre-cancerous lesions of the cervix.
European Journal of Cancer Prevention. 2000
Cervical screening: how often should women be screened?.
Cytopathology. 2000
Report on consensus conference on cervical cancer screening and management.
International Journal of Cancer. 2000
Cervical cancer risk: is there a genetic component?.
Molecular Medicine Today. 2000
Cervical cancer.
American Family Physician. 2000
MediFocus Guides... When You Need Trustworthy Medical Information


MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.






MediFocus MedCenter ©

 Colorectal Cancer
(OC007)
Introduction


Cancer of the colon and rectum is the third leading cause of cancer worldwide, with an estimated 150,000 new cases every year. When detected early, colorectal cancer is highly treatable and curable. Most colon cancers arise from adenomatous polyps. About 5% of adenomatous polyps are estimated to become malignant and this process takes approximately 10 years.

Cancer can grow inward toward the hollow part of the colon or rectum, and/or outward through the walls of these organs. Advanced disease can cause perforation of the bowel, leading to infection. Metastasis (spread) of the disease may occur to the lymph nodes, liver, lung, peritoneum, ovaries, and brain.

There are several types of colorectal cancer:
Adenocarcinomas
Carcinoid tumors
Gastrointestinal stromal tumors
Lymphomas

The choice of treatment may depend on the individual's situation and current overall health status. However, for the majority of reasonably healthy persons with mild to moderate disease, aggressive treatment with a goal of cure is the plan. Treatment usually consists if a combination of surgery, radiation and/or chemotherapy.

Get the Facts... With your MediFocus Guide


The Medifocus Guide on Colorectal Cancer provides answers to the following important questions and medical issues:

What are the most common symptoms of colorectal cancer?
Are there any recognized risk factors for developing colorectal cancer?
What kinds of medical tests are used to establish the diagnosis of colorectal cancer?
What is the current standard of care for the treatment of colorectal cancer?
What treatment options are available for the management of colorectal cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in colorectal cancer?
Where are the leading hospitals and centers of research for colorectal cancer?
What are the most important questions to ask my doctor about colorectal cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Radioimmunotherapy of colorectal cancer liver metastases: combination with radiotherapy.
Annals of the New York Academy of Sciences. 2000
Different pathways of colorectal carcinogenesis and their clinical pictures.
Annals of the New York Academy of Sciences. 2000
Recent advances of molecular biology in colorectal cancer.
Gan to Kagaku Ryoho [Japanese Journal of Cancer & Chemotherapy]. 2000
Diagnosis of colorectal neoplasms at double-contrast barium enema examination.
Radiology. 2000
Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999.
Archives of Pathology & Laboratory Medicine. 2000
Molecular and clinical risk markers in colon cancer trials.
European Journal of Cancer. 2000
Colorectal cancer: update on recent advances and their impact on screening protocols.
Journal of the National Medical Association. 2000
Colorectal cancer follow-up: perspectives for future studies.
European Journal of Surgical Oncology. 2000
Postoperative colorectal cancer surveillance.
Journal of the American College of Surgeons. 2000
What's new with tumor markers for colorectal cancer?.
Digestive Surgery. 2000
MediFocus Guides... When You Need Trustworthy Medical Information


MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.




MediFocus MedCenter ©

 Ductal Carcinoma in Situ (DCIS)
(OC008)
Introduction


Breast cancer is the most common cancer among women, other than skin cancer. It is the second leading cause of cancer death in women after lung cancer. The American Cancer Society predicts that there will be about 182,000 new cases of invasive breast cancer in the year 2000. Fortunately, deaths from breast cancer have declined significantly, which is though to be due to better detection and improved treatment.

Ductal carcinoma in situ (DCIS), also called intraductal carcinoma, is early breast cancer that is confined to the ducts. Best diagnosed by a mammogram, DCIS carries a nearly 100% cure rate.

Screening by breast exam and regular mammogram as recommended greatly increases the chance of early diagnosis and is important for women of all ages.

Once a breast cancer is diagnosed, the focus of care depends on the stage of disease and the personal goals of the individual. An elderly woman with a less aggressive type of cancer may wish to avoid aggressive treatments and pursue palliative treatments, while for a younger woman, aggressive therapy targeted at achieving remission is usually desired.

Treatment strategy depends on the stage of disease and the goals of care for the individual. Treatment usually consists of a combination of surgery, medication, radiation, and/or chemotherapy.

Get the Facts... With your MediFocus Guide


The Medifocus Guide on Ductal Carcinoma in Situ provides answers to the following important questions and medical issues:

What are the most common symptoms of breast cancer?
Are there any recognized risk factors for developing breast cancer?
What kinds of medical tests are used to establish the diagnosis of breast cancer?
What is the current standard of care for the treatment of breast cancer?
What treatment options are available for the management of breast cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in breast cancer?
Where are the leading hospitals and centers of research for breast cancer?
What are the most important questions to ask my doctor about breast cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

The diagnosis and management of ductal carcinoma in-situ of the breast.
Ca: a Cancer Journal for Clinicians. 2000
Ductal carcinoma in situ (DCIS) of the breast: evolving perspectives.
Cancer Treatment Reviews. 2000
Detection of stromal invasion in breast cancer: the myoepithelial markers.
Advances in Anatomic Pathology. 2000
Intraductal papillary-mucinous tumors: an entity which is infrequent and difficult to diagnose.
Hepato-Gastroenterology. 2000
Consensus Conference on the Treatment of In Situ Ductal Carcinoma of the Breast, April 22-25, 1999.
Cancer. 2000
Treatment of early-stage breast cancer.
Current Problems in Cancer. 1999
The management of ductal and lobular breast cancer.
Surgical Oncology. 1999
Ductal carcinoma in situ of the breast.
BMJ. 1998
Standards for diagnosis and management of ductal carcinoma in situ (DCIS) of the breast. American College of Radiology. American College of Surgeons. College of American Pathologists. Society of Surgical Oncology.
Ca: a Cancer Journal for Clinicians. 1998
The management of ductal carcinoma in situ (DCIS). The Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. Canadian Association of Radiation Oncologists.
CMAJ. 1998
MediFocus Guides... When You Need Trustworthy Medical Information


MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.




MediFocus MedCenter ©

 Glioblastoma
(OC009)
Introduction


Astrocytomas are tumors that arise from astrocyte cells - part of the supportive (neuroglial) tissue of the brain. Astrocytomas account for about half of all primary tumors of the brain and spinal cord.

Glioblastomas are fast growing astrocytomas that contain areas of dead tumor cells (necrosis). Glioblastoma Multiforme (GBM), the most common type of grade IV tumor, tends to invade adjacent brain tissue and to spread throughout the central nervous system. Variants of GBM include gliosarcomas and giant cell glioblastomas.

GBMs occur most often in the cerebrum, especially in the frontal and temporal lobes of the brain. They rarely occur in the brain stem or cerebellum.

GBM represents about 30% of all primary brain tumors and about 50% of the astrocytomas. It is more common in older adults and affects more men than women. Nine percent of childhood brain tumors are glioblastomas.

Glioblastomas can be very difficult to treat. Methods include surgery, chemotherapy, surgery and steroids.

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The Medifocus Guide on Glioblastoma provides answers to the following important questions and medical issues:

What are the most common symptoms of glioblastoma?
Are there any recognized risk factors for developing glioblastoma?
What kinds of medical tests are used to establish the diagnosis of glioblastoma?
What is the current standard of care for the treatment of glioblastoma?
What treatment options are available for the management of glioblastoma?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in glioblastoma?
Where are the leading hospitals and centers of research for glioblastoma?
What are the most important questions to ask my doctor about glioblastoma?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Post-traumatic malignant glioma: case report and review of the literature.
British Journal of Neurosurgery. 2000
Future directions in the treatment of malignant gliomas with temozolomide.
Seminars in Oncology. 2000
Temozolomide in malignant gliomas.
Seminars in Oncology. 2000
Clinical cure of glioblastoma--two case reports.
Neurologia Medico-Chirurgica. 2000
Phenotype vs genotype in the evolution of astrocytic brain tumors.
Toxicologic Pathology. 2000
Glioblastoma multiforme in a case of acquired immunodeficiency syndrome: investigation a possible oncogenic influence of human immunodeficiency virus on glial cells. Case report and review of the literature.
Journal of Neurosurgery. 2000
Favorable outcome of giant cell glioblastoma in a child. Report of an 11-year survival period.
Childs Nervous System. 1998
Long-term survival in cerebral glioblastoma. Case report and critical review of the literature.
Tumori. 1998
Long-term survival in patients with supratentorial glioblastoma.
Journal of Neuro-Oncology. 1998
Radiosurgery for primary malignant brain tumors.
Seminars in Surgical Oncology. 1998
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MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.




MediFocus MedCenter ©

 Laryngeal Cancer
(OC010)
Introduction


Laryngeal cancer affects more than 12,000 persons every year in the U.S., and occurs in men more often than women. That is because the two main risk factors are smoking and alcohol abuse, which, in the past, have been more common among men than women. As these habits increase among women, the risk for these cancers also increases.

Cancers of the larynx are defined by the location:
Supraglottis (the tissue above the glottis)
Glottis (the middle part of the larynx where the vocal cords are located)
Subglottis (the tissue below the glottis that connects the larynx to the trachea)

There are different types of laryngeal cancer
Squamous Cell Carcinoma (accounts for 95% of cases)
Adenocarcinoma
Sarcoma

Treatment for laryngeal cancer usually consists of surgery, radiation, and/or chemotherapy. Often, a combination of approaches is used depending on the stage of the disease and the presence of other medical conditions that may limit a person's ability to tolerate certain treatments.

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The Medifocus Guide on Laryngeal Cancer provides answers to the following important questions and medical issues:

What are the most common symptoms of laryngeal cancer?
Are there any recognized risk factors for developing laryngeal cancer?
What kinds of medical tests are used to establish the diagnosis of laryngeal cancer?
What is the current standard of care for the treatment of laryngeal cancer?
What treatment options are available for the management of laryngeal cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in laryngeal cancer?
Where are the leading hospitals and centers of research for laryngeal cancer?
What are the most important questions to ask my doctor about laryngeal cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Recurrent respiratory papillomatosis of the larynx: current diagnosis and treatment.
Otolaryngologic Clinics of North America. 2000
Nonsurgical treatment of advanced metastatic cervical disease in cancer of the larynx.
2000
Surgical treatment of the neck in cancer of the larynx.
2000
The pathology of neck dissection in cancer of the larynx.
2000
Diagnostic procedures for detection of lymph node metastases in cancer of the larynx.
2000
The pathology and management of subglottic cancer.
European Archives of Oto-Rhino-Laryngology. 2000
Asbestos exposure and laryngeal cancer.
Annals of Occupational Hygiene. 2000
Markers in cancer of the larynx and pharynx.
Clinical Otolaryngology & Allied Sciences. 2000
Granular cell tumors of the larynx.
Journal of Voice. 2000
Comparing treatment outcomes of radiotherapy and surgery in locally advanced carcinoma of the larynx: a comparison limited to patients eligible for surgery.
International Journal of Radiation Oncology, Biology, Physics. 2000
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MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.




MediFocus MedCenter ©

 Non-Small Cell Lung Cancer
(OC011)
Introduction


The American Cancer Society predicts that there will be about 164,100 new cases of lung cancer in the United States in the year 2000. Lung cancer is fairly rare in persons under the age of 40. The average age of persons found to have lung cancer is 60.

Non-small Cell Lung Cancer accounts for about 80% of all lung cancers.

Lung cancer is usually treated with a combination of modalities (i.e., surgery and chemotherapy and radiation) It is becoming more common to undergo a course of radiation or chemotherapy before surgery to reduce the number of cancer cells that may have the potential to spread.

Smoking is the single most important risk factor for the development of lung cancer. Persons who smoke cigarettes, pipes or cigars should consult with their health care provider about methods to quit as soon as possible.

A variety of complementary therapies have been used by persons with all types of cancer to reduce side effects of treatments such as nausea and pain. Biofeedback and other relaxation therapies as well as acupuncture have been used to reduce stress, anxiety and general discomfort.

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The Medifocus Guide on Non-Small Cell Lung Cancer provides answers to the following important questions and medical issues:

What are the most common symptoms of lung cancer?
Are there any recognized risk factors for developing lung cancer?
What kinds of medical tests are used to establish the diagnosis of lung cancer?
What is the current standard of care for the treatment of lung cancer?
What treatment options are available for the management of lung cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in lung cancer?
Where are the leading hospitals and centers of research for lung cancer?
What are the most important questions to ask my doctor about lung cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Evidence-based medicine in the treatment of non-small-cell lung cancer.
Clinics in Chest Medicine. 2000
Innovative treatment strategies in locally advanced and/or unresectable non-small cell lung cancer.
Cancer Control. 2000
Pathogenesis and management of respiratory insufficiency following pulmonary resection.
Seminars in Surgical Oncology. 2000
Role of multimodality treatment for lung cancer.
Seminars in Surgical Oncology. 2000
Combined modality therapy of non-small cell lung cancers.
Annals of Oncology. 1999
Neoadjuvant and adjuvant trials in non-small cell lung cancer.
Annals of Thoracic Surgery. 1998
Serum interleukin-10 levels as a prognostic factor in advanced non-small cell lung cancer patients.
Chest. 2000
Unfavorable prognosis of patients with stage II non-small cell lung cancer associated with macroscopic nodal metastases.
Chest. 1999
Relationship between quality of life and clinical outcomes in advanced non-small cell lung cancer: best supportive care (BSC) versus BSC plus chemotherapy.
Lung Cancer. 1999
The prognosis of surgically resected N2 non-small cell lung cancer: the importance of clinical N status.
Journal of Thoracic & Cardiovascular Surgery. 1999
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MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.




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 Ovarian Cancer
(OC012)
Introduction


Ovarian cancer affects approximately 25,000 women every year. Although the peak age at the time of diagnosis of ovarian cancer is 57 years, 10% of women are younger than age 35 at the time of diagnosis.

The epithelial cancers, or adenocarcinomas, account for 85% of all ovarian cancers but rarely occur in women younger than age 30 years. Approximately 15% of all epithelial cancers are low malignant potential tumors, which are often found early.

The more common ovarian neoplasms in young women are the germ cell malignancies. In fact, these can occur in young children and account for more than 85% of all ovarian malignancies in girls younger than 15 years of age.

Achievement of total remission or cure is the ultimate goal of therapy. In the woman of childbearing age, consideration is given to the desire for reproductive capability, which is preserved if possible.

Treatment for ovarian cancer usually involves surgery and chemotherapy. Some women with very early stage disease may be treated with surgery alone.

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The Medifocus Guide on Ovarian Cancer provides answers to the following important questions and medical issues:

What are the most common symptoms of ovarian cancer?
Are there any recognized risk factors for developing ovarian cancer?
What kinds of medical tests are used to establish the diagnosis of ovarian cancer?
What is the current standard of care for the treatment of ovarian cancer?
What treatment options are available for the management of ovarian cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in ovarian cancer?
Where are the leading hospitals and centers of research for ovarian cancer?
What are the most important questions to ask my doctor about ovarian cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Current management of epithelial ovarian carcinoma: a review.
Seminars in Surgical Oncology. 2000
Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology.
Virchows Archiv. 2000
Ovarian mucinous cystadenocarcinoma as a cause of Zollinger-Ellison syndrome: report of a case and review of the literature.
American Journal of Gastroenterology. 2000
Chemotherapy for advanced ovarian cancer. Advanced Ovarian Cancer Trialists Group.
Cochrane Database of Systematic Reviews [computer file]. 2000
The genetics, screening, and treatment of epithelial ovarian cancer: an update.
Cleveland Clinic Journal of Medicine. 2000
Serum markers as prognostic factors in epithelial ovarian cancer: an overview.
European Journal of Gynaecological Oncology. 2000
Second-line treatment of ovarian cancer.
Oncologist. 2000
Major oncogenes and tumor suppressor genes involved in epithelial ovarian cancer (review).
International Journal of Oncology. 2000
Primary and salvage therapy with LH-RH analogues in ovarian cancer.
Recent Results in Cancer Research. 2000
Forthnightly review: hereditary ovarian carcinoma.
BMJ. 1999
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MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.







MediFocus MedCenter ©

 Pancreatic Cancer
(OC013)
Introduction


The pancreas serves two functions in the body. It produces digestive juices that help digest food, and hormones (such as insulin) that regulate how the body stores and uses food.

The area of the pancreas that produces digestive juices is called the exocrine pancreas. These juices contain enzymes that break down fats and proteins in the diet so the nutrients can be absorbed by the small intestine and used by the body to repair tissues or grow. The exocrine ducts that carry this pancreatic juice to the common bile duct and eventually to the small intestine.

A small percentage of the cells in the pancreas are endocrine cells. These cells are arranged in small clusters called islets. The islet cells release two hormones, insulin and glucagon, that are important in controlling the amount of sugar in the blood.

About 95% of pancreatic cancers begin in the exocrine pancreas. There are several types of tumors that can develop in the exocrine pancreas. Tumors of the endocrine pancreas are much less common.

The American Cancer Society estimates that 28,3000 Americans will be diagnosed with cancer of the pancreas in the year 2000.

Treatment of pancreatic cancer usually consists of a combination of surgery, radiation, chemotherapy, hormone therapy, and hepatic arterial occlusion.

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The Medifocus Guide on Pancreatic Cancer provides answers to the following important questions and medical issues:

What are the most common symptoms of pancreatic cancer?
Are there any recognized risk factors for developing pancreatic cancer?
What kinds of medical tests are used to establish the diagnosis of pancreatic cancer?
What is the current standard of care for the treatment of pancreatic cancer?
What treatment options are available for the management of pancreatic cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in pancreatic cancer?
Where are the leading hospitals and centers of research for pancreatic cancer?
What are the most important questions to ask my doctor about pancreatic cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Pancreatic cancer: state-of-the-art care.
Ca: a Cancer Journal for Clinicians. 2000
Resectable carcinoma of the pancreatic head developing 7 years and 4 months after distal pancreatectomy for carcinoma of the pancreatic tail.
Journal of Hepato-Biliary-Pancreatic Surgery. 2000
Roles of gastrointestinal hormones in pancreatic cancer.
Journal of Hepato-Biliary-Pancreatic Surgery. 2000
Spindle cell carcinoma of the pancreas.
Journal of Hepato-Biliary-Pancreatic Surgery. 2000
Large acinar cell carcinoma of the pancreas in a patient with elevated serum AFP level.
Journal of Hepato-Biliary-Pancreatic Surgery. 2000
Macrocystic serous cystadenoma of the pancreas.
Journal of Hepato-Biliary-Pancreatic Surgery. 2000
Pancreaticoduodenal resection.
Journal of Hepato-Biliary-Pancreatic Surgery. 2000
Laparoscopy and peritoneal cytology in the staging of pancreatic cancer.
Journal of Hepato-Biliary-Pancreatic Surgery. 2000
Can we screen high-risk individuals to detect early pancreatic carcinoma?.
Journal of Surgical Oncology. 2000
Chemotherapy in the treatment of neuroendocrine malignant tumors.
Digestion. 2000
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MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.




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 Prostate Cancer, Early Stage
(OC024)
Introduction


Carcinoma of the prostate is the most commonly diagnosed male malignancy in the US. In 1998, there were 184,000 new cases diagnosed. In fact, prostate cancer is a common incidental finding at autopsy (70% of men aged 80). Because it grows so slowly, it often produces no symptoms and men often die of other causes before the cancer becomes an issue.

The cause of prostate cancer remains unclear. It is thought to be a combination of environmental, genetic, and lifestyle factors. Men are at the highest risk between ages 40 and 60. Men with a first-degree relative who had the disease and African American men are also at higher risk.

The decision to aggressively evaluate and treat a prostate cancer depends on several factors, including age, life expectancy, general health status, stage of the tumor, the desire to maintain erectile function, the individual wishes of the man regarding the desire for cure versus palliation.

Aggressive treatment usually includes surgery, and/or radiation, and/or hormonal therapy. Less aggressive therapy may consist of hormone therapy alone, either at the time of diagnosis or later, when symptoms appear.

The decision to monitor symptoms and progression of the disease is called "watchful waiting". This is a reasonable option in elderly men with low-grade tumors and men with other medical illnesses that reduce life expectancy to less than 10 years.

Get the Facts... With your MediFocus Guide


The Medifocus Guide on Prostate Cancer, Early Stage provides answers to the following important questions and medical issues:

What are the most common symptoms of prostate cancer?
Are there any recognized risk factors for developing prostate cancer?
What kinds of medical tests are used to establish the diagnosis of prostate cancer?
What is the current standard of care for the treatment of prostate cancer?
What treatment options are available for the management of prostate cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in prostate cancer?
Where are the leading hospitals and centers of research for prostate cancer?
What are the most important questions to ask my doctor about prostate cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Early prostate cancer.
Current Problems in Cancer. 2000
Early prostate cancer diagnosis and therapy.
Advances in Internal Medicine. 2000
Recent advances in early prostatic cancer.
Anticancer Research. 1999
Rising PSAs after primary therapy: active or passive intervention.
Seminars in Urologic Oncology. 1999
Treatment options for early prostate cancer.
Urology. 1998
Early-stage prostate cancer: controversies, confusion, and difficult choices.
Cancer Journal From Scientific American. 1998
Diagnosis and treatment of prostate cancer.
American Family Physician. 1998
Stage T1c prostate cancer: defining the appropriate staging evaluation and the role for pelvic lymphadenectomy.
World Journal of Urology. 1997
Diagnosis, management and screening of early localised prostate cancer.
Health Technology Assessment (South Hampton, NY). 1997
Predicting pelvic lymph node involvement in patients with localized prostate cancer.
European Urology. 1997
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MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.





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 Prostate Cancer, Localized
(OC014)
Introduction


Carcinoma of the prostate is the most commonly diagnosed male malignancy in the US. In 1998, there were 184,000 new cases diagnosed. In fact, prostate cancer is a common incidental finding at autopsy (70% of men aged 80). Because it grows so slowly, it often produces no symptoms and men often die of other causes before the cancer becomes an issue.

The cause of prostate cancer remains unclear. It is thought to be a combination of environmental, genetic, and lifestyle factors. Men are at the highest risk between ages 40 and 60.

The decision to aggressively evaluate and treat a prostate cancer depends on several factors, including age, life expectancy, general health status, stage of the tumor, the desire to maintain erectile function, the individual wishes of the man regarding the desire for cure versus palliation.

Aggressive treatment usually includes surgery, and/or radiation, and/or hormonal therapy. Less aggressive therapy may consist of hormone therapy alone, either at the time of diagnosis or later, when symptoms appear.

The decision to monitor symptoms and progression of the disease is called "watchful waiting". This is a reasonable option in elderly men with low-grade tumors and men with other medical illnesses that reduce life expectancy to less than 10 years. Palliative measures may be used to control progression and symptoms of the disease without pursuing a cure as the goal of treatment.

Get the Facts... With your MediFocus Guide


The Medifocus Guide on Prostate Cancer, Localized provides answers to the following important questions and medical issues:

What are the most common symptoms of prostate cancer?
Are there any recognized risk factors for developing prostate cancer?
What kinds of medical tests are used to establish the diagnosis of prostate cancer?
What is the current standard of care for the treatment of prostate cancer?
What treatment options are available for the management of prostate cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in prostate cancer?
Where are the leading hospitals and centers of research for prostate cancer?
What are the most important questions to ask my doctor about prostate cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Current status of minimally invasive treatment options for localized prostate carcinoma.
European Urology. 2000
Treatment of prostate cancer: watchful waiting, radical prostatectomy, and cryoablation.
Seminars in Surgical Oncology. 2000
Recent advances in the treatment of prostate cancer.
Annals of Oncology. 1999
Prostate cancer.
Medical Clinics of North America. 1999
Have complication rates decreased after treatment for localized prostate cancer?.
Journal of Urology. 1999
Advances in prostate cancer.
Current Opinion in Oncology. 1999
Therapeutic options in locally defined or advanced prostate cancer.
European Urology. 1999
The challenge of locally advanced prostate cancer.
Seminars in Oncology. 1999
Treatment of locally advanced prostate cancer: is chemotherapy the next step?.
Journal of Clinical Oncology. 1999
Evaluation and management of the man who has failed primary curative therapy for prostate cancer.
Urologic Clinics of North America. 1998
MediFocus Guides... When You Need Trustworthy Medical Information


MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.





MediFocus MedCenter ©

 Prostate Cancer, Metastatic
(OC015)
Introduction


Carcinoma of the prostate is the most commonly diagnosed male malignancy in the US. In 1998, there were 184,000 new cases diagnosed. In fact, prostate cancer is a common incidental finding at autopsy (70% of men aged 80). Because it grows so slowly, it often produces no symptoms and men often die of other causes before the cancer becomes an issue.

The cause of prostate cancer remains unclear. It is thought to be a combination of environmental, genetic, and lifestyle factors. Men are at the highest risk between ages 40 and 60.

The decision to aggressively evaluate and treat a prostate cancer depends on several factors, including age, life expectancy, general health status, stage of the tumor, the desire to maintain erectile function, the individual wishes of the man regarding the desire for cure versus palliation.

The first decision is how aggressively the cancer is to be treated. Aggressive treatment usually includes surgery, and/or radiation, and/or hormonal therapy. Less aggressive therapy may consist of hormone therapy alone, either at the time of diagnosis or later, when symptoms appear.

Palliative measures such as orchiectomy (removal of the testes) or hormone therapy may be used to control progression and symptoms of the disease without pursuing a cure as the goal of treatment.

Get the Facts... With your MediFocus Guide


The Medifocus Guide on Prostate Cancer, Metastatic provides answers to the following important questions and medical issues:

What are the most common symptoms of prostate cancer?
Are there any recognized risk factors for developing prostate cancer?
What kinds of medical tests are used to establish the diagnosis of prostate cancer?
What is the current standard of care for the treatment of prostate cancer?
What treatment options are available for the management of prostate cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in prostate cancer?
Where are the leading hospitals and centers of research for prostate cancer?
What are the most important questions to ask my doctor about prostate cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Medical therapy of prostate cancer: 1999.
Journal - South Carolina Medical Association. 2000
Management of advanced prostate cancer.
Oncologist. 2000
New treatment strategies in advanced prostate cancer.
Radiologic Clinics of North America. 2000
Prostate cancer.
Medical Clinics of North America. 1999
Supportive care, pain management, and quality of life in advanced prostate cancer.
Urologic Clinics of North America. 1999
Advances in prostate cancer.
Current Opinion in Oncology. 1999
Treatment options in androgen-independent prostate cancer.
Cancer Investigation. 1999
Prostate cancer: 9. Treatment of advanced disease.
CMAJ. 1999
Hormone-refractory prostate cancer: an evolving standard of care.
Seminars in Oncology. 1999
Approaches to the treatment of patients with hormone-sensitive prostate cancer.
Seminars in Oncology. 1999
MediFocus Guides... When You Need Trustworthy Medical Information


MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.






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 Renal Cell Carcinoma
(OC016)
Introduction


There are several different types of cancer that can affect the kidney. Renal cell carcinoma (RCC) is the most common type, affecting approximately 40,000 persons every year in the United States. However, it is not a very common type of cancer overall.

RCC, also called renal adenocarcinoma or hypernephroma, is the development of cancerous changes in the cells of the renal tubules. These are the functional units of the kidneys where urine is formed and consist of structures called nephrons and collecting tubules.

As kidney cancer grows, it may invade organs near the kidney such as the liver, colon, or pancreas. Kidney cancer cells may also spread to areas away from the original site (metastasize) such as the lymph nodes, brain, lungs or bone.

Surgery is the mainstay of treatment for RCC, although usually a combination of treatment modalities is utilized. Outcome is greatly improved when the cancer is caught early, before metastases have occurred.

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The Medifocus Guide on Renal Cell Carcinoma provides answers to the following important questions and medical issues:

What are the most common symptoms of renal cell carcinoma?
Are there any recognized risk factors for developing renal cell carcinoma?
What kinds of medical tests are used to establish the diagnosis of renal cell carcinoma?
What is the current standard of care for the treatment of renal cell carcinoma?
What treatment options are available for the management of renal cell carcinoma?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in renal cell carcinoma?
Where are the leading hospitals and centers of research for renal cell carcinoma?
What are the most important questions to ask my doctor about renal cell carcinoma?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Novel investigative approaches for advanced renal cell carcinoma.
Seminars in Oncology. 2000
Renal cell carcinoma.
Current Opinion in Oncology. 1999
Renal cell carcinoma: management of advanced disease.
Journal of Urology. 1999
Genitourinary malignancies.
Cancer Chemotherapy & Biological Response Modifiers. 1999
Renal-cell carcinoma in children: a different disorder from its adult counterpart?.
Medical & Pediatric Oncology. 1998
Renal cell carcinoma.
Current Opinion in Oncology. 1998
Clinical practice guidelines: renal cell carcinoma.
Cleveland Clinic Journal of Medicine. 1997
Report of 337 patients with renal cell carcinoma emphasizing 110 with stage IV disease and review of the literature.
Journal of Surgical Oncology. 1997
Management of renal cell carcinoma.
Oncology (Huntington). 2000
Prognostic factors in renal cell and bladder cancer.
BJU International. 1999
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MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.




MediFocus MedCenter ©

 Small Cell Lung Cancer
(OC018)
Introduction


The American Cancer Society predicts that there will be about 164,100 new cases of lung cancer in the United States in the year 2000. Lung cancer is fairly rare in persons under the age of 40. The average age of persons found to have lung cancer is 60.

Small Cell Lung Cancer accounts for about 20% of all lung cancers and is a more aggressive type.

Lung cancer is usually treated with a combination of modalities (i.e., surgery and chemotherapy and radiation) It is becoming more common to undergo a course of radiation or chemotherapy before surgery to reduce the number of cancer cells that may have the potential to spread.

Smoking is the single most important risk factor for the development of lung cancer. Persons who smoke cigarettes, pipes or cigars should consult with their health care provider about methods to quit as soon as possible.

A variety of complementary therapies have been used by persons with all types of cancer to reduce side effects of treatments such as nausea and pain. Biofeedback and other relaxation therapies as well as acupuncture have been used to reduce stress, anxiety and general discomfort.

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The Medifocus Guide on Small Cell Lung Cancer provides answers to the following important questions and medical issues:

What are the most common symptoms of lung cancer?
Are there any recognized risk factors for developing lung cancer?
What kinds of medical tests are used to establish the diagnosis of lung cancer?
What is the current standard of care for the treatment of lung cancer?
What treatment options are available for the management of lung cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in lung cancer?
Where are the leading hospitals and centers of research for lung cancer?
What are the most important questions to ask my doctor about lung cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Current guidelines for the management of small cell lung cancer.
Mayo Clinic Proceedings. 1999
New perspectives for the pharmacological and biological therapy of small cell lung cancer.
Critical Reviews in Oncology-Hematology. 1999
Review of selected randomized trials in small cell lung cancer.
Seminars in Oncology. 1998
Small-cell lung cancer: treatment progress and prospects.
Oncology. 1998
Current therapy of small cell lung cancer.
Current Opinion in Oncology. 1998
Prognostic significance of supraclavicular lymph nodes in small cell lung cancer: a study from four consecutive clinical trials, including 1,370 patients. "Petites Cellules" Group.
Chest. 1998
Lung cancer in women compared with men: stage, treatment, and survival.
Annals of Thoracic Surgery. 1998
Normal serum neuron specific enolase (NSE) value after the first cycle of chemotherapy: an early predictor of complete response and survival in patients with small cell lung carcinoma.
Cancer. 1998
Outcome of patients with small-cell lung cancer during 20 years of clinical research at the US National Cancer Institute.
Mayo Clinic Proceedings. 1997
Nonpharmacologic management of chemotherapy-induced nausea and vomiting.
Oncology Nursing Forum. 1997
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MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.




MediFocus MedCenter ©

 Tongue Cancer
(OC022)
Introduction


The oral cavity and oropharynx contain several types of tissue and each of these tissues contains several types of cells. Different cancers can develop from each kind of cell. The differences are important, because they influence treatment options and outlook for recovery.

More than 90% of cancers of the oral cavity and oropharynx are squamous cell carcinomas, also called squamous cell cancer. Squamous cell cancer begins as a collection of abnormal squamous cells. The earliest form of squamous cell cancer is called carcinoma in situ meaning that the cancer cells are present only in the lining layer of cells called the epithelium. Invasive squamous cells cancer means that the cancer cells have spread beyond this layer into deeper layers of the oral cavity or oropharynx.

The American Cancer Society estimates about 30,200 new cases (20,000 in men and 10,000 in women) or oral cavity and pharyngeal cancer will be diagnosed in the United States during 2000.

Treatment usually requires a combination of surgery and radiation, chemotherapy and/or cryotherapy (freezing).

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The Medifocus Guide on Tongue and Oral Cancers provides answers to the following important questions and medical issues:

What are the most common symptoms of oral cancer?
Are there any recognized risk factors for developing oral cancer?
What kinds of medical tests are used to establish the diagnosis of oral cancer?
What is the current standard of care for the treatment of oral cancer?
What treatment options are available for the management of oral cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in oral cancer?
Where are the leading hospitals and centers of research for oral cancer?
What are the most important questions to ask my doctor about oral cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Tumors of the oral cavity and pharynx.
World Journal of Surgery. 2000
Intraoral liposarcoma: case report and review of the literature.
2000
Primary osteogenic sarcoma of the tongue.
Journal of Laryngology & Otology. 1999
Squamous carcinoma of the tongue: review.
British Journal of Oral & Maxillofacial Surgery. 1999
A multidisciplinary approach to head and neck cancer.
European Journal of Cancer Care (English Language Edition). 1998
Cancer of the tongue in patients less than forty.
Head & Neck. 2000
Lipoma of the tongue.
Otolaryngology - Head & Neck Surgery. 2000
Carcinoma of the tongue: the speech therapist's perspective.
British Journal of Oral & Maxillofacial Surgery. 1999
Management of Jehovah's Witness patients undergoing major head and neck surgery.
Head & Neck. 1999
Cancer of the base of the tongue: past and future.
Head & Neck. 1999
MediFocus Guides... When You Need Trustworthy Medical Information


MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.




MediFocus MedCenter ©

 Uterine Cancer
(OC023)
Introduction


Uterine cancer typically involved the endometrium or inner lining of the uterus. Endometrial cancer is the most common gynecologic malignancy. Cancer may also affect the muscle of the uterus (uterine sarcoma) or the cervix (which is not discussed in this report).

Uterine cancer has the potential to spread to other areas of the body either by spreading or by cells breaking away from the original location. This is known as metastasis. Uterine cancer may spread to nearby organs such as the bladder or colon, or cells may break away and travel to the lungs, liver, or bones.

It is estimated that 37,400 women developed uterine cancer in the United States in 1999. Fortunately, most cases are diagnosed at an early stage, when surgery alone may be adequate for cure. The rate of 5-year survival for women with Stage I endometrial cancer is as high as 95%.

Surgery is the primary method of treatment for most women with uterine cancer, although additional therapies are being developed to offer options for women who wish to maintain reproductive capability. Adjuvant therapies may be needed in addition to surgery for women with advanced disease.

Get the Facts... With your MediFocus Guide


The Medifocus Guide on Uterine Cancer provides answers to the following important questions and medical issues:

What are the most common symptoms of uterine cancer?
Are there any recognized risk factors for developing uterine cancer?
What kinds of medical tests are used to establish the diagnosis of uterine cancer?
What is the current standard of care for the treatment of uterine cancer?
What treatment options are available for the management of uterine cancer?
Are there any promising new developments or potential breakthroughs in treatment?
Who are the most notable medical authorities who specialize in uterine cancer?
Where are the leading hospitals and centers of research for uterine cancer?
What are the most important questions to ask my doctor about uterine cancer?
What Your Doctor Reads:


This MediFocus Guide contains an extensive listing of citations and abstracts of recent journal articles that have been published about this condition in trustworthy medical journals. This is the same type of information that is available to physicians and other health care professionals. A partial selection of journal articles that are abstracted in this MediFocus Guide includes:

Long-term tamoxifen treatment: a possible aetiological factor in the development of uterine carcinosarcoma: two case-reports and review of the literature.
Anticancer Research. 2000
Endometrial cancer. Prevention, detection, management, and follow up.
Canadian Family Physician. 2000
Problems in the differential diagnosis of endometrial hyperplasia and carcinoma.
Modern Pathology. 2000
Non-Hodgkin's lymphomas involving the uterus: a clinicopathologic analysis of 26 cases.
Modern Pathology. 2000
The pathology of uterine smooth muscle tumors and mixed endometrial stromal-smooth muscle tumors: a selective review with emphasis on recent advances.
International Journal of Gynecological Pathology. 2000
Primary uterine angiosarcoma.
Gynecologic Oncology. 1999
HRT and women who have had breast or endometrial cancer.
Journal of Epidemiology & Biostatistics. 1999
Endocrine therapy for gynecological cancer.
Gynecological Endocrinology. 1999
Endometrial cancer: recent developments in evaluation and treatment.
Oncology (Huntington). 1999
Contemporary issues in the management of endometrial cancer.
Ca: a Cancer Journal for Clinicians. 1998
MediFocus Guides... When You Need Trustworthy Medical Information


MediFocus.com understands that consumers who are facing serious medical issues need access to credible, up-to-date medical information to help them make informed health-care decisions. That's why we've developed the MediFocus Guides...the most advanced and trustworthy patient research guides for over 200 chronic and life-threatening conditions. Each MediFocus Guide includes a detailed overview of the condition including information about diagnosis, treatment options, cutting-edge research, and new developments; excerpts of important journal articles from the current medical literature focusing on standard treatments and treatment options; a directory of leading authors and medical institutions who specialize in the treatment of the condition; and a listing of organizations and support groups where you can obtain additional information about the illness.

MediFocus Guides are the perfect solution for consumers who wish to gain an in-depth understanding of their medical issue and avail themselves of the same type of professional level medical information that is used by physicians and other health-care professionals to help then in the clinical decision making process.
© Copyright 2000-2001 Medifocus.com, Inc. All rights reserved.

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